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Highlights This study systematically expounded the main mechanism of action of Ganoderma lucidum polysaccharides in treating diabetic complications

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IL-1, on the other hand, has been shown to interfere with the ion selectivity of tight junctions (Coyne et al., 2002), and, in combination with High Mobility Group Box 1 (HMGB1), induces the downregulation of occludin and claudin-1 and the mislocalization of E-cadherin and -catenin (HUANG et al., 2016)